XMRV Retrovirus: Round up 21: CFSAC videocasts, Testing, Media, CDC Chatter Blog

XMRV Retrovirus   Whittemore Peterson   Institute Science   Mikovits   Peterson   Chronic Fatigue Syndrome

XMRV Retrovirus: Round up 21: CFSAC videocasts, Testing, Media and CDC Chatter Blog

WordPress Shortlink: http://wp.me/p5foE-2iU

Videocasts of CFSAC meeting 29-30 October 2008

Around 12 hours of video of the two day CFSAC meeting is now available at:

http://videocast.nih.gov/PastEvents.asp

Chronic Fatigue Syndrome Advisory Committee Meeting (CFSAC) – Day 1
Thursday, October 29, 2009
HHS Office on Women’s Health (OWH)
Total Running Time: 06:43:49

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http://videocast.nih.gov/PastEvents.asp

Chronic Fatigue Syndrome Advisory Committee Meeting (CFSAC) – Day 2
Friday, October 30, 2009
HHS Office on Women’s Health (OWH)
Total Running Time: 05:15:09

Presentation

Dr David Bell’s PowerPoint slides: http://www.hhs.gov/advcomcfs/meetings/agendas/bell_factitious_102909.ppt

Public Testimony
Thursday, October 29, 2009

List of those given testimony plus some PDFs

Friday, October 30, 2009

List of those given testimony plus some PDFs

Written Testimony Received Prior to the Meeting Date

26 PDFs

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YouTubes of CFSAC meeting

Clips of Dr Dan Peterson’s presentation and Annette Whittemore: http://www.youtube.com/user/Khalyal

Also on this channel plus some patient testimonies: http://www.youtube.com/user/luminescentfeeling

Dr Dan Peterson presentation in 11 parts here: http://www.youtube.com/user/luminescentfeeling#p/u/11/80yKflt0tcA

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Media

Reno Gazette Journal  | 3 November 2009

http://www.rgj.com/article/20091103/NEWS/911030349/1321/news

Hundreds request test for retrovirus
BY LENITA POWERS • lpowers@rgj.com

Overwhelmed by requests from people seeking to have their blood tested for a new retrovirus discovered by researchers at the Whittemore-Peterson Institute for Neuro-Immune Disease in Reno, the institute has arranged for a local laboratory to do the testing.

The flood of requests for blood tests began after the Whittemore-Peterson Institute published a research study in the Oct. 8 online journal Science that showed the prevalence of the retrovirus XMRV in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Viral Immune Pathology Diagnostics (VIP Dx), a small state-certified laboratory in Reno, temporarily will provide testing for the retrovirus XMRV for physicians who request it for their patients at a cost ranging from $400 to $650.

Institute officials said the hope to enter an agreement with a larger laboratory that could handle the demand nationwide, Annette Whittemore, the institute’s founder and president, said Monday…

Read full article here

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ProHealth  |  3 November 2009

http://www.prohealth.com/library/showarticle.cfm?libid=14982

Dr. Bell’s November Newsletter – Lyndonville Research Group ‘Back in Business’ with Presentations Planned

Issued in the wee hours of November 3, 2009, Dr. David Bell’s latest free Lyndonville News e-newsletter (http://www.davidsbell.com/index.htm#Latest  announces that the revived Lyndonville ME/CFS Research Group has already initiated four projects, the first being a presentation Dr. Bell will give Sunday, Dec 6 in Batavia, New York “Between Rochester and Buffalo,” fee $10 to cover costs…

Read full article here

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University of Florida  College of Medicine  |  3 November 2009

http://news.medinfo.ufl.edu/articles/miscellaneous/event/chronic-fatigue-syndrome-cancer-linked-to-new-virus/

By Czerne Reid

A newly identified virus has been found to be linked to chronic fatigue syndrome and might also provide clues about how to prevent prostate cancer, according to a report this month in the journal Science. Called XMRV, the virus is transmitted in blood and body fluids and might be a significant public health threat.

Judy Mikovits, Ph.D., senior author of the paper, described the research during grand rounds at the University of Florida College of Medicine Thursday, Oct. 20. She was a guest of the division of hematology/oncology…

Read full article here

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Reuters Hemispherx Press Release

http://www.reuters.com/article/pressRelease/idUS124102+02-Nov-2009+GNW20091102

Hemispherx Biopharma Updates Chronic Fatigue Syndrome (CFS) Treatment and Commercial…

Mon Nov 2, 2009 8:46am EST

Hemispherx Biopharma Updates Chronic Fatigue Syndrome (CFS) Treatment and Commercial Application Programs

PHILADELPHIA, Nov. 2, 2009 (GLOBE NEWSWIRE) — Hemispherx Biopharma, Inc. (NYSE Amex:HEB) (the “Company”), announced a two-prong CFS clinical mission for November and December 2009.

The Company plans to widen its ongoing clinical programs in CFS by accelerating collaborations with a consortium of researchers who have just discovered a retroviral link to Chronic Fatigue Syndrome (please see October 8, 2009, online issue of Science). A clinically validated test to detect retrovirus antibodies in patients plasma is also currently under development (please see US National Institutes of Health at:
http://www.cancer.gov/newscenter/pressreleases/CFSxmrv ).

With the consortium of researchers at the Whittemore Peterson Institute, the Company is also now evaluating the defect in immunosurveillance in specific subsets of CFS patients in a clinical study entitled “Therapeutic Activation of NK lymphocytes to Alleviate Chronic Fatigue Syndrome.” These immune defects may be due to the previously undetected retrovirus…

Read full Press Release here

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About.com  Fibromyalgia  and CFS Blog  | November 3, 2009

http://chronicfatigue.about.com/b/2009/11/03/chronic-fatigue-syndrome-dr-lerner-on-ampligen-xmrv.htm

Chronic Fatigue Syndrome: Dr. Lerner on Ampligen, XMRV

By Adrienne Dellwo, About.com Guide to Fibromyalgia & CFS

Dr. A Martin Lerner: Thoughts on XMRV (Updated), Ampligen

In my recent conversation with Dr. A. Martin Lerner, a former chronic fatigue syndrome sufferer who says he used his specialty in infectious diseases to find treatments for himself and others, I asked him about both the XMRV discovery (which was just days old at the time) and also about Ampligen, the proposed chronic fatigue syndrome drug currently awaiting FDA approval…

Read full article here

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Commentary

From Hillary Johnson, author of “Osler’s Web”:

Website: http://oslersweb.com/

Blog: http://oslersweb.com/blog.htm

2 October 2009 via Co-Cure

“I’ve posted a new blog, “CDC MYOCARDIAL INFARCTION,” which reveals agency staff anxiety over the likelihood of reprisals against the CDC for Bill Reeves’ two-decades con job.

http://www.oslersweb.com/blog.htm?post=643435

“The material comes from an internal CDC web site where anonymous posters chat about what worries them. Over the weekend, several people have sent me comments captured from this site before it was shut down on October 29th.”*

Stephen Ralph, of MEActionUK, also presents a comprehensive link to this site, at: http://www.meactionuk.org.uk/CDC_Chatter_Blog_-_Updated_021109.htm

Ed: Note: The site has not been shut down but access to this particular thread is no longer set for public access.

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For initial Whittemore Peterson Press Release, NIH (National Institutes of Health) News Release, Science paper go here: http://wp.me/p5foE-272

Click here for all previous XMRV Round ups and postings in reverse date order: https://meagenda.wordpress.com/category/xmrv/

The Definition Petition

Petition webpage: http://CFSdefinitionpetition.notlong.com
i.e. http://www.ipetitions.com/petition/empirical_defn_and_CFS_research

If you haven’t already signed it – sign the CFS Definition Petition today at: http://CFSdefinitionpetition.notlong.com

XMRV Retrovirus: Round up 19: XMRV Blood Safety and Availability from HHS (US), PhD study

XMRV Retrovirus Whittemore Peterson Institute Science Mikovits Chronic Fatigue Syndrome

XMRV Retrovirus: Round up 19: XMRV Blood Safety and Availability from HHS (US), PhD study

WordPress Shortlink for this posting: http://wp.me/p5foE-2gR

Click here to download Lombardi Science paper

Or Open PDF here: Lombardi Science study

Supporting materials for Lombardi paper here: Supporting materials from Science

Perspectives article here: Science Express Perspective

For initial Whittemore Peterson Press Release, NIH (National Institutes of Health) News Release, Science paper go here: http://wp.me/p5foE-272

Click here for all previous XMRV Round ups and postings in reverse date order:

https://meagenda.wordpress.com/category/xmrv/

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XMRV Blood Safety and Availability from HHS (US)

On the CFIDS Association site

http://www.facebook.com/CFIDSAssn#/CFIDSAssn?v=app_2347471856

Xenotropic Murine LeukemiaVirus-Related Virus (XMRV)
Blood Safety and Availability
Office of Public Health and Science
Department of Health and Human Services (HHS)
Jerry A. Holmberg, PhD, SBB
October 30, 2009
30 October 2009

The Office of Public Health and Science’s Blood Safety and Availability is aware of the recent literature suggesting linkage of chronic fatigue syndrome to a possible contagious rodent retrovirus, XMRV. XMRV has also been associated with an aggressive form of prostate cancer. Antibodies against the virus have been detected in 3.7% of healthy controls in a study of a small number of individuals. Currently there is no commercially available test for infection with XMRV. While there is no known association of CFS or prostate cancer with history of transfusion, the finding that the virus is associated with white blood cells has led some to question whether XMRV could be transmitted by transfusion and might therefore pose a threat to the health of blood recipients and potentially also transplant recipients.

The HHS Blood Safety Committee works with all the PHS agencies (i.e., CDC, FDA, HRSA, and NIH) to ensure the safety and availability of blood products as well as transplantation safety. Under the leadership of that committee, steps are being taken to investigate the blood safety threat from XMRV and the potentially protective role of white cell removal, which is performed on approximately 70% of blood. An interagency Emerging Infectious Diseases working group that reports to the Blood Safety Committee is currently assessing the literature on XMRV, conducting meetings with experts on this retrovirus, and interacting with groups that could study the question of blood safety. A report is expected within several weeks. In particular, the National Heart Lung and Blood Institute Retrovirus Epidemiology Donor Study-II (REDS-II) investigators are aware of the report in Science and are assessing the prevalence of XMRV in blood donors to determine whether studies aimed at evaluating transfusion-transmission rate are warranted using NHLBI’s repositories of donor and recipient blood samples.

HHS will remain vigilant in assessing the safety of the blood supply and developing interventions as appropriate.

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Links to Other Federal Guidelines

National Cancer Institute Interim Guidelines on XMRV:
http://www.cfids.org/temp/xmrv-guidelines-nci.asp 

NIH Fact Sheet on Transfusion Safety (general): http://www.nih.gov/about/researchresultsforthepublic/Transfusion.pdf

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PhD Project, University College London

PDF here

http://www.findaphd.com/search/showproject.asp?projectid=18971  

Dept/SchoolDivision of Infection & Immunity, University College London
Project Supervisor(s) Prof G Towers
Dr P Kellam

Funding Availability Competition Funded Project (European/UK Students Only)

Application Deadline 23 November 2009

A role for XMRV in human disease

Laboratory supervisor: Prof Greg Towers

Clinical supervisor: Prof Deenan Pillay

Xenotropic murine retrovirus (XMRV) has recently been associated with chronic fatigue syndrome as well as prostate carcinoma in humans (1-3). XMRV is a murine endogenous virus found in the genome of mice and until recently has been thought to be absent from the human population. It is now becoming clear that XMRV has transmitted to humans by a process of zoonosis, presumably from mice, and appears to be associated with a variety of diseases not previously associated with viral infection.

1. We will establish quantitative PCR assays and serology assays including enzyme linked immunosorbant assays (ELISA) to detect and quantify XMRV. Importantly, assays used to detect related murine leukaemia viruses in the lab are expected to be suitable.

2. We will use these assays to measure XMRV load in chronic fatigue patient samples as well as, well but XMRV infected control samples, with a view to establishing whether viral load relates to disease, episodes of illness and/or severity.

3. The receptor for XMRV has been identified. We will seek human polymorphism in the xenotropic receptor and assess which human cells express it. We will also establish which cells in vivo in blood express the receptor and which cells are infected with XMRV by quantitative PCR on sorted subsets of B and T cells from XMRV infected individuals.

This project proposes to address some of the most important questions surrounding the recently described XMRV infection of humans and to seek a therapeutic strategy for XMRV treatment. We expect it to be a competitive project and the experiments performed are likely to be influenced by ongoing studies published as we go. We expect that the candidate will be fully trained in modern techniques of molecular virology during the course of this project.

TO APPLY Send THREE COPIES of your CV (including full contact details of two academic referees) a personal statement and an indication of your top two preferences, on a separate page, from the list of projects below to:

Isabel Lubeiro, Division of Infection & Immunity, Windeyer Building, 46 Cleveland Street, London W1T 4JF.
CLOSING DATE: 23 NOVEMBER 2009

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Media

From Dr Marc-Alexander Fluks via Co-Cure

Source: Irish Medical Times
Date: October 29, 2009
Author: Garrett FitzGerald
URL: http://www.imt.ie/opinion/2009/10/retrovirus_may_shed_light_on_m.html

Retrovirus may shed light on mystery of chronic fatigue

Back in the news big-time is Chronic Fatigue Syndrome. A recent paper in Science reports infection with a gammaretrovirus (XMRV) in 67 per cent of cases. The virus has been detected from blood and saliva in long-term sufferers.

Is it time to apologise to all the patients who were diagnosed as being somewhat cracked? I recall one colleague referring to the condition as the Muirisheen Durkan syndrome: So, goodbye Muirisheen Durkan I’m sick and tired of workin’!

For some unknown reason, I was sent many patients with the syndrome from all over the country. I was almost always impressed by the genuine nature of the symptoms, having no doubt that there just had to be something other than psychological reasons underneath.

I could do nothing for them

I listened (often the consultation lasted more than an hour) and in most instances after investigation told the patients that they were probably suffering from CFS/ME. I told them I could do nothing for them in terms of cure or alleviation. The only contribution I made was to warn them about the quacks which they (understandably) were attending or about to attend.

One patient was attending a great man in London, who claimed he was a physician to the Queen (lucky ol’ Queen), who kept admitting the patient to private hospitals over there for infusions of vitamins and Lord knows what else.

There was no improvement, surprisingly, in a well-nourished, fruit- eating young female whose gums were not bleeding onto the tablecloth. He would tell her that she hadn’t had enough courses of the infusions just yet, to stick with them. The patient had sold her house and was in the process of selling her car to pay the fees for this Hippocratic artiste.

Money-mad mountebanks

My intervention did nothing for the symptoms, but the patient got to hold on to her car. Many fell into the clutches of money-mad mountebanks, chancers, crystal-ball gazers and three-card-trick merchants. Regrettably, most of these were practicing medical doctors.

Some patients who had previously been leading a fully active and productive life were reduced to being little better than bed-ridden. The Royal College of Psychiatrists classified the condition as (partly) a psychiatric illness about 20 years ago and recommended courses of psychotherapy.

In earlier papers, there was some response to the sessions, most patients saying that they were a little better.

Some of my patients were depressed. Their symptoms sometimes responded to SSRIs, but they were left with their original degree of fatigue unchanged. Some patients seemed to remit spontaneously after anything from two to 20 years after the onset of the condition.

Accepted the diagnoses

A rare patient improved substantially with psychiatrist-prescribed Prozac in doses exceeding 80mg/day. Most did not improve. In fairness, both the Departments of Health and Social Welfare accepted the diagnoses of ME/Post-viral Syndrome/CFS as grounds for awarding disability benefits.

Specialists in Internal Medicine generally recommended a program which included increasing amounts of physical exercise. My own experience was that almost none of the patients could walk more than the length of themselves without ‘paying’ for it – having to recover in bed for two or three days.

The ME patients’ support group lobbied well for their members, but were despondent about the future. Many patients felt ridiculed (by the attitude of some professionals) and concealed the diagnosis. Many had by then lost their livelihoods and their own self-respect and self-worth.

One swallow does not a summer make. Before deciding that the retrovirus is actually causative, we await the outcome of further studies. If these are confirmatory, we wait for the results of trials of anti-retroviral therapy. As always, the thinking doctor will be cautious.

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From Dr John Greensmith via Co-Cure

Letter link:

http://www.bexhillobserver.net/letters-to-the-editor/Your-letters–October-23.5761548.jp 

(Scroll down long way, 18 of 20 letters to “Beware Study”)

Title: Beware Study, Letters, Bexhill-on-Sea Observer, 23 October 2009

Text:

Further to the recent article about a research study carried out in America that suggests a link between a retrovirus and ME (Does a virus cause ME?, Bexhill Observer, 14 October 2009), after consulting with our medical advisers people with the illness should be aware that, while very interesting and encouraging, these findings do need to be replicated in other laboratories.

This is not the first time that a retrovirus has been suggested to play a major part in ME, and before it was sadly found to be a false dawn.

We also need to be aware that, even if an association is confirmed we don’t yet know if it is a cause or a consequence  of ME. It would be premature to think about tests and treatments until we know very much more.

On the other hand, this finding will encourage more biomedical research that will increase our understanding of ME. The message from our advisers is that although this is a very interesting advance, we should not get too excited about it until we know more.

There is much that can be done to help those with ME, as a survey run by our charity recently in the area shows.

For more information call 01273 674828 or see www.measussex.org.uk 

Colin Barton
Chairman
Sussex ME/CFS Society

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CFSAC meeting Days One and Two

Videocasts of the entire proceedings will be available shortly from the NIH wesbite. I will post the links for these once these are online (RealPlayer required): http://videocast.nih.gov/PastEvents.asp

Dr David Bell’s presentation PowerPoint Slides can be viewed here:

http://www.hhs.gov/advcomcfs/meetings/agendas/bell_factitious_102909.ppt

 

YouTubes

Clips of Dr Dan Peterson’s presentation and Annette Whittemore: http://www.youtube.com/user/Khalyal

Also on this channel plus some patient testimonies: http://www.youtube.com/user/luminescentfeeling

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Whittemore Peterson Website Q & A

http://www.wpinstitute.org/xmrv/xmrv_qa.html

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CFIDS Association of America

Website: http://www.cfids.org/ 

On Facebook: http://www.facebook.com/CFIDSAssn

Facebook Notes page (includes notes on CFSAC meeting):

http://www.facebook.com/CFIDSAssn#/CFIDSAssn?v=app_2347471856

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Patient community websites, blogs and forums

Cort Johnson’s website: http://aboutmecfs.org/Conf/IACFSME09WPI.aspx

The IACFS/ME Conference II: the Hit of the Conference
The Whittemore-Peterson Neuro-Immune Institute

Reno, Nevada: March 12-16, 2009

Forums: http://forums.aboutmecfs.org/index.php

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The Definition Petition

Petition webpage: http://CFSdefinitionpetition.notlong.com
i.e. http://www.ipetitions.com/petition/empirical_defn_and_CFS_research

If you haven’t already signed it – sign the CFS Definition Petition today at: http://CFSdefinitionpetition.notlong.com

XMRV Retrovirus: CFSAC meeting Day Two

XMRV   Retrovirus   Whittemore Peterson Institute   Science   Mikovits   Chronic Fatigue Syndrome

XMRV Media Round up 18    WordPress Shortlink: http://wp.me/p5foE-2fR

Click here for all previous XMRV Media Round ups: https://meagenda.wordpress.com/category/xmrv/

 

XMRV Retrovirus: CFSAC meeting Day Two

The Chronic Fatigue Syndrome Advisory Committee (CFSAC) provides advice and recommendations to the Secretary of Health and Human Services via the Assistant Secretary for Health of the U.S. Department of Health and Human Services on issues related to chronic fatigue syndrome (CFS).

Wanda K. Jones, DrPH is the CFSAC Designated Federal Official Deputy Assistant Secretary for Health – Women’s Health. For more information, visit http://www.hhs.gov/advcomcfs

For those who won’t be attending Day Two of the CFSAC meeting, today, Friday 30th October, the meeting is being videocast. Time displayed on the NIH site is Eastern Time, Washington DC Local. UK is currently 4 hours ahead of Washington DC  – so 9:00 a.m. Washington DC is 13:00 hours UK time.

If you’re not able to catch all of today’s meeting or missed parts of yesterday’s, videocasts of the entire proceedings will be available shortly from the NIH wesbite ( http://videocast.nih.gov/PastEvents.asp ). I will post the links once these are online. 

The CFCAS meeting will begin to stream live from the meeting room a few minutes before 1.00 p.m. UK time, with the audio off.  Microphones are turned on just before the meeting is called to order – so don’t think you haven’t got sound. There are simultaneous subtitles.  Today’s meeting is scheduled to adjourn at 4.00 p.m. Washington time (8.00 p.m. UK time). To watch the full day’s proceedings go to this link and scroll down to:

http://videocast.nih.gov/    RealPlayer required

Chronic Fatigue Syndrome Advisory Committee Meeting (CFSAC) – Day 2

Day 2 Friday 30th October   9:00 a.m. to 4:00 p.m.

 

Agendas for Day One and Day Two are here:   AGENDA

http://www.hhs.gov/advcomcfs/meetings/agendas/cfsac091029_agenda.html  

Yesterday’s meeting included presentations by Dr Dan Peterson, Dr John Coffin (co-author of the Science “Perspective” article) and Dr David Bell, who spoke on MSpB (FII).

Dr Bell’s PowerPoint Slides can be viewed here:

http://www.hhs.gov/advcomcfs/meetings/agendas/bell_factitious_102909.ppt 

 

YouTube

Clips of Dr Dan Peterson and Annette Whittemore:  http://www.youtube.com/user/Khalyal

7 uploads so far

Also here with some patient testimonies:

http://www.youtube.com/user/luminescentfeeling#p/u/2/80yKflt0tcA

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Whittemore Peterson Website Q & A

http://www.wpinstitute.org/xmrv/xmrv_qa.html

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Kelly reports via Co-Cure  29 October 2009

“An investigative journalism site in Atlanta just posted the following article about the CDC and Reeves.”

Atlanta unfiltered

http://www.atlantaunfiltered.com/2009/10/28/advocates-where-was-cdc-for-milestone-in-chronic-fatigue-syndrome-research/

Advocates: Where was CDC for milestone in chronic fatigue syndrome research?

October 28, 2009 –

Looks like the CDC’s chronic fatigue syndrome research group, led by Dr. William C. Reeves, may have some ‘splaining to do today in Washington. A possible research breakthrough — the discovery of a correlation between CFS and a retrovirus related to the AIDS virus — has fired up the medical community in recent weeks. “This is going to create an avalanche of subsequent studies,” Dr. William Schaffner, an infectious disease expert at Vanderbilt University, told the New York Times this month. But will the Centers for Disease Control and Prevention play a role in that research? It hasn’t so far.

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Patient community websites, blogs, commentaries

Cort Johnson’s Phoenix Rising website

Resources, Blog and Forums

http://aboutmecfs.org/Rsrcs/XMRVResources.aspx

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Hillary Johnson, author of Osler’s Web

http://www.oslersweb.com/blog.htm?post=641747

Inside the Labyrinth
BILL REEVES: THE DECIDER

October 24, 2009

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Peggy Munson

“First, Do No Pharma”

http://peggymunson.blogspot.com/

Peggy Munson
Saturday, October 17, 2009

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CFS Patient Advocate

http://cfspatientadvocate.blogspot.com/2009/10/xmrv.html

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Dr Marc-Alexander reports via Co-Cure 

Source: NCBI PubMed
Date: 27 oktober 2009
URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
Topic: XMRV
Ref: The list below illustrates that so far, just 16 papers have been published on the XMRV.

XMRV papers published up to october 27, 2009

Hohn O, Krause H, Barbarotto P, Niederstadt L, Beimforde N, Denner J, Miller K, Kurth R, Bannert N.
Lack of evidence for xenotropic murine leukemia virus-related virus (XMRV) in German prostate cancer patients.
Retrovirology. 2009 Oct 16;6(1):92.

Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Silverman RH, Mikovits JA.
Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome.
Science. 2009 Oct 8.

Yan Y, Liu Q, Kozak CA.
Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor.
Retrovirology. 2009 Oct 7;6(1):87.

Schlaberg R, Choe DJ, Brown KR, Thaker HM, Singh IR.
XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors.
Natl Acad Sci U S A. 2009 Sep 22;106(38):16351-6.

Stang A, Petrasch-Parwez E, Brandt S, Dermietzel R, Meyer HE, Stuhler K, Liffers ST, Uberla K, Grunwald T.
Unintended spread of a biosafety level 2 recombinant retrovirus.
Retrovirology. 2009 Sep 22;6:86.

Hong S, Klein EA, Das Gupta J, Hanke K, Weight CJ, Nguyen C, Gaughan C, Kim KA, Bannert N, Kirchhoff F, Munch J, Silverman RH.
Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus related virus), a human retrovirus associated with prostate cancer.
J Virol. 2009 Jul;83(14):6995-7003.

Knouf EC, Metzger MJ, Mitchell PS, Arroyo JD, Chevillet JR, Tewari M,
Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells.
J Virol. 2009 Jul;83(14):7353-6.

Bisbal C, Salehzada T.
RNase L, a crucial mediator of innate immunity and other cell functions [French].
Med Sci (Paris). 2008 Oct;24(10):859-64.

Fischer N,  Hellwinkel O, Schulz C, Chun FK, Huland H, Aepfelbacher M, Schlomm T.
Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.
J Clin Virol. 2008 Nov;43(3):277-83.

Dong B, Silverman RH, Kandel ES.
A natural human retrovirus efficiently complements vectors based on murine leukemia virus.
PLoS One. 2008 Sep 4;3(9):e3144.

Kim S, Kim N, Dong B, Boren D, Lee SA, Das Gupta J, Gaughan C, Klein EA, Lee C, Silverman RH, Chow SA.
Integration site preference of xenotropic murine leukemia virus- related virus, a new human retrovirus associated with prostate cancer.
J Virol. 2008 Oct;82(20):9964-77.

Summers K, Crespi B.
Molecular evolution of the prostate cancer susceptibility locus RNASEL: evidence for positive selection.
Infect Genet Evol. 2008 May;8(3):297-301.

McCormick AL, Brown RH Jr, Cudkowicz ME, Al-Chalabi A, Garson JA.
Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate.
Neurology. 2008 Jan 22;70(4):278-83.

Silverman RH.
A scientific journey through the 2-5A/RNase L system.
Cytokine Growth Factor Rev. 2007 Oct-Dec;18(5-6):381-8.

Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH.
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.
 Natl Acad Sci U S A. 2007 Jan 30;104(5):1655-60.

Urisman A,  Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL.
Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
PLoS Pathog. 2006 Mar;2(3):e25. Epub 2006 Mar 31.

(c) 2009 NCBI PubMed

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The Definition Petition

Petition webpage: http://CFSdefinitionpetition.notlong.com
i.e. http://www.ipetitions.com/petition/empirical_defn_and_CFS_research

If you haven’t already signed it – sign the CFS Definition Petition today at: http://CFSdefinitionpetition.notlong.com

XMRV Retrovirus: What’s coming up?

 @ 3.07 pm  UK time  Dr. John Coffin about to start

(Published Online October 8, 2009, Science DOI: 10.1126/science.1181349, Science Express Index

Perspectives, Submitted on July 14, 2009, Accepted on August 31, 2009

A New Virus for Old Diseases? John M. Coffin 1* and Jonathan P. Stoye 2)

Update @  2.26 pm  UK time  Dan Peterson XMRV presentation about to start

Perspective on XMRV and Human Retroviruses  Dr. John Coffin Tufts University Boston, Massachusetts scheduled to follow on from Dan Peterson’s presentation.

Update @ 1.oo pm  UK time

CFCAS meeting about to start and is already live streaming from meeting room with simultaneous subtitles click here:

http://videocast.nih.gov/   RealPlayer required

 

Click here for   AGENDA

http://www.hhs.gov/advcomcfs/meetings/agendas/cfsac091029_agenda.html  

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XMRV   Retrovirus   Whittemore Peterson Institute   Science   Mikovits   Chronic Fatigue Syndrome

XMRV Retrovirus: What’s coming up?

WordPress Shortlink: http://wp.me/p5foE-2fa

Media

News4

http://www.krnv.com/Global/story.asp?S=11402586

Reno scientists prepare to address federal health officials

Victoria Campbell  |  News 4  |  28 October 2008

Just weeks after a medical breakthrough that pinpointed a virus that may be linked to Chronic Fatigue Syndrome, the doctor who helped lead the medical team is preparing to present his findings to an advisory committee from the U.S. Department of Health and Human Services… Read full article here

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CFCAS meeting

For those who won’t be attending the CFSAC meeting, on Thursday 29th and Friday 30th October, the meeting is being videocast at the following links:

UK is currently 4 hours time difference with Washington DC  – so 9:00 a.m. Washington DC is 13:00 hours UK time.

Day 1 Thursday 29th October   9:00 a.m. to 5:00 p.m.

http://videocast.nih.gov/summary.asp?live=7908

Dr Daniel Peterson’s presentation is scheduled for 10:15 a.m.

Dr David Bell’s presentation is scheduled for 3:30 p.m.

Dr Bell’s PowerPoint Slides can be viewed here:

http://www.hhs.gov/advcomcfs/meetings/agendas/bell_factitious_102909.ppt

 

Day 2 Friday 30th October   9:00 a.m. to 4:00 p.m.

http://videocast.nih.gov/summary.asp?live=7909

The number of computers logging on and watching are going to be counted by the NIH. For those who aren’t able to watch live, archived video will be available at:

http://videocast.nih.gov/PastEvents.asp

Click here for   AGENDA

http://www.hhs.gov/advcomcfs/meetings/agendas/cfsac091029_agenda.html  

CFSAC Agenda – October 29-30, 2009

U.S. Department of Health and Human Services

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Video of University of the Pacific Public Presentation on the XMRV/CFS discoveries

On 26 October, Dr Judy Mikovits gave a Public Presentation on the XMRV/CFS discoveries at the University of the Pacific. It’s understood that a videocast of the presentation (which is said to have included new material not yet reported on) will shortly be available.  I will update once the video has been released.

News Release here:

15 October 2008

http://web.pacific.edu/x31783.xml

Fatigue Syndrome Researchers to Speak on Campus

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The Definition Petition

Petition webpage: http://CFSdefinitionpetition.notlong.com
i.e. http://www.ipetitions.com/petition/empirical_defn_and_CFS_research

If you haven’t already signed it – sign the CFS Definition Petition today at: http://CFSdefinitionpetition.notlong.com

XMRV Retrovirus Whittemore Peterson CFS study Media Round up 12

XMRV Retrovirus Whittemore Peterson CFS study Media Round up: 12

WordPress Shortlink: http://wp.me/p5foE-2c2

Media

ABC News

http://abcnews.go.com/video/playerIndex?id=8864348

Good Morning America [ABC] -XMRV

ABCNews 

Click here for interview with Dr. Donnica Moore about the link between the XMRV and ME/CFS

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New York Times

http://www.nytimes.com/2009/10/21/opinion/21johnson.html?pagewanted=2&_r=2

http://tinyurl.com/ykw4msd

October 21, 2009

Op-Ed Contributor
A Case of Chronic Denial
By HILLARY JOHNSON

EARLIER this month, a study published in the journal Science answered a question that medical scientists had been asking since 2006, when they learned of a novel virus found in prostate tumors called xenotropic murine leukemia virus-related virus, or XMRV: Was it a human infection?

XMRV is a gammaretrovirus, one of a family of viruses long-studied in animals but not known to infect people. In animals, these retroviruses can cause horrendous neurological problems, immune deficiency, lymphoma and leukemia. The new study provided overwhelming evidence that XMRV is a human gammaretrovirus – the third human retrovirus (after H.I.V. and human lymphotropic viruses, which cause leukemia and lymphoma). Infection is permanent and, yes, it can spread from person to person (though it is not yet known how the virus is transmitted).

That would have been news enough, but there was more…

Read full commentary by Hillary Johnson, author of Osler’s Web here

While you’re on the NYT site, email Hillary’s commentary to family, friends and contacts!

Hillary Johnson’s website here: http://oslersweb.com
Hillary Johnson blogs at: http://oslersweb.com/blog.htm

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From Martin L. (Marty) Pall, via Co-Cure

21 October 2009

Mikovits and her colleagues published a paper and accessory materials in the journal Science, a highly respected journal and have also provided additional and in some cases more recent information elsewhere. In the Science publication they report that the XMRV retrovirus occurs in about 2/3rds of CFS/ME patients but only in 3.7% of normal controls. They also report that subsequently, using a more sensitive assay, XMRV occurs in over 90% of CFS/ME patients – we don’t know what the percentage is for normal controls using that more sensitive assay.

The virus was originally isolated from some aggressive prostate cancer cells. In addition, in unpublished data, it is also apparently shows high prevalence in fibromyagia patients and in atypical multiple sclerosis (MS) patients.

Comment: These data apparently show that XMRV is not specific for CFS/ME but rather occurs in other disease states, as well as in some normals. My own view is that this makes it much more likely to be an opportunistic disease, caused by the changes in immune function and other properties of these diseases, rather than a primary cause. Specifically, the retrovirus, based on its DNA sequence, has its replication stimulated by NF-kappaB activity, an activity that is elevated as part of the NO/ONOO- cycle and has been reported to be elevated in CFS/ME. Furthermore, the low NK cell activity and other types of immune dysfunction, that occurs in these various diseases,  may also be expected to stimulate the ability of the virus to maintain itself in disease sufferers.

In order to show that it is the primary cause of CFS/ME, it is necessary to show that XMRV follows Koch’s postulates, but so far it does not apparently follow Koch’s first postulate, which requires that it always occurs in people with the disease but does not occur in normals. The other three Koch’s postulates have not been tested.

In contrast to that, we have a good fit to the five principles underlying the NO/ONOO- cycle for both CFS/ME and fibromyalgia. Because one can argue that the fit to these five principles serve very much like Koch’s postulates for NO/ONOO- cycle disease, I will argue that we have a substantially more compelling case for a NO/ONOO- cycle etiology than we do for an XMRV infectious etiology for either CFS/ME or fibromyalgia.

That does not mean that XMRV is unimportant, however. Even if it turns out to be an opportunistic infection, like mycoplasma and HHV-6 are, it still may contribute to the etiology of the disease. And it still raises the question of whether we can cure cases of CFS/ME and fibromyalgia simply by normalizing the NO/ONOO- cycle as opposed to normalizing it and also using antivirals to depress XMRV and/or HHV-6. This is a question and I don’t claim to have the answer to it, although my hope is that normalizing the cycle will also cure at least some of these infections, that may not be true.

There have been comments in the media to the effect that this finally shows that CFS/ME is physiological, not psychological. This is true, but this should have been obviously true anyway, at least six or seven years ago. Nevertheless the media coverage of CFS/ME obtained by Mikovits and her colleagues must be viewed as a true gift to those interested in extending public knowledge of this disease.

Martin L. (Marty) Pall

Dr. Martin Pall’s NO/ONOO- Theory/Treatment Discussion Group: http://health.groups.yahoo.com/group/TenthParadigmSociety

The Tenth Paradigm – Dr. Martin Pall’s Website for CFS/MCS/FM/ETC: http://www.thetenthparadigm.org

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NIH

http://www.nih.gov/researchmatters/october2009/10192009cfs.htm

October 19, 2009

Virus Linked to Chronic Fatigue Syndrome

Scientists have detected the DNA of a retrovirus in the blood of patients with chronic fatigue syndrome. The discovery raises the possibility that the virus may be a contributing factor in chronic fatigue syndrome.

Transmission electron micrograph of round virus particles.

XMRV virus particles seen by transmission electron microscopy. Image courtesy of University of Utah Health Sciences Public Affairs.

Chronic fatigue syndrome, or CFS, is a debilitating disease that affects millions of people in the United States. It’s characterized by profound fatigue that doesn’t improve with bed rest and can be exacerbated or re-kindled by physical or mental activity. A number of other symptoms are also associated with CFS, including cognitive deficits, impaired sleep, myalgia, arthralgia, headache, gastrointestinal symptoms and tender lymph nodes.

No specific cause for CFS has yet been identified. However, patients with CFS are known to have some abnormalities in their immune system. Recently, scientists found evidence of a virus called xenotropic murine leukemia virus-related virus, or XMRV, in the tumors of patients with prostate cancer. Some patients with XMRV-positive prostate cancer were reported to have a specific immune system defect that was also seen in CFS patients. Suspecting a link between the virus and CFS, a team of scientists from the Whittemore Peterson Institute at the University of Nevada, NIH’s National Cancer Institute (NCI) and the Cleveland Clinic set out to look for the virus in blood samples.

The scientists identified DNA from XMRV in the blood cells of 68 of 101 (67%) CFS patients, as reported in the online edition of Science on October 8, 2009. In contrast, the blood of only 8 out of 218 healthy people (3.7%) contained XMRV. Blood cells not only contained XMRV DNA, but also expressed XMRV proteins and produced infectious viral particles.

The researchers also found that XMRV stimulates immune responses in people with CFS. Plasma from 9 out of 18 CFS patients infected with XMRV reacted with a viral protein, whereas none of the plasma from 7 healthy donors showed a reaction.

“These compelling data allow the development of a hypothesis concerning a cause of this complex and misunderstood disease, since retroviruses are a known cause of neurodegenerative diseases and cancer in man,” says Dr. Francis Ruscetti of NCI, who worked on the project.

Retroviruses like XMRV have also been shown to activate a number of other latent viruses. This could explain why so many different viruses, such as Epstein-Barr virus, have been associated with CFS.

The researchers cautioned, however, that while this study found an association between XMRV and CFS, further work will be needed to determine whether XMRV truly contributes to the development of CFS.

“The discovery of XMRV in 2 major diseases, prostate cancer and now chronic fatigue syndrome, is very exciting,” says Dr. Robert H. Silverman, a co-author at the Cleveland Clinic. If a role for XMRV is established, there could be new opportunities for prevention and treatment of these diseases.

Related Links:
Chronic fatigue syndrome:
http://orwh.od.nih.gov/cfs/aboutcfs.html

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Patient community websites and blogs

Cort Johnson’s Phoenix Rising website

http://aboutmecfs.org/Rsrcs/XMRVResources.aspx

Cort Johnson’s Blog and comments

http://aboutmecfs.org/blog/?p=990

“A supernova (pl. supernovae) is a stellar explosion. Supernovae are extremely luminous and cause a burst of radiation that often briefly outshines an entire galaxy”. This discovery has the potential for being a world changing event in every way for chronic fatigue syndrome patients. If it really works out – still an if – one almost has to think in inter-galactic terms to find an appropriate analogy of how different things could be five years from now…”

Check out “The Potential of XMRV” in the latest edition of ‘Bringing the Heat’ from Phoenix Rising.

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This is ME – rutts tankespinn

http://merutt.wordpress.com/tag/chronic-fatigue-syndrome/

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Previous ME agenda Media Round ups

Round up 12: XMRV Retrovirus Whittemore Peterson CFS study Media Round up 12: http://wp.me/p5foE-2c2

Round up 11: XMRV Retrovirus Whittemore Peterson CFS study Media Round up 11: http://wp.me/p5foE-2bB

Round up 10: Whittemore Peterson Institute XMRV retrovirus study link with CFS (Science journal):
http://wp.me/p5foE-2bk

Round up 9: Notice from Dr David Bell, Lyndonville News; Article by Paul R. Cheney MD, PhD:
http://wp.me/p5foE-2aQ

Round up 8: XMRV retrovirus study: Position statement from ME Association 14.10.09: http://wp.me/p5foE-2at

Round up 7: XMRV Retrovirus: Whittemore Peterson Institute: CFS: Media Round up 7: http://wp.me/p5foE-2aa 

Round up 6: XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study: Videos and audios: http://wp.me/p5foE-29L 

Round up 5: Supporting Online Material for XMRV Chronic Fatigue Syndrome study: http://wp.me/p5foE-299

Round up 4: XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study:
http://wp.me/p5foE-28F

Round up 3: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome retrovirus XMRV in the media: http://wp.me/p5foE-280

Round up 2: Science 9 October 2009: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome link to retrovirus: 08.10.09: http://wp.me/p5foE-27v

Round up 1: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome link to retrovirus: 09.10.09: http://wp.me/p5foE-272

XMRV Retrovirus: Notice from Dr David Bell Lyndonville News; Article by Dr Paul Cheney MD

XMRV Retrovirus: Notice from Dr David Bell, Lyndonville News; Article by Dr Paul R. Cheney MD, PhD plus Media Round up 9

WordPress Shortlink: http://wp.me/p5foE-2aQ

Media Round up

New Scientist    8 October 2009 by Ewen Callaway

http://www.newscientist.com/article/dn17947-chronic-fatigue-syndrome-linked-to-cancer-virus.html

Chronic fatigue syndrome linked to ‘cancer virus’

“Chronic fatigue syndrome, the debilitating condition once dismissed as “yuppie flu”, has been linked to a virus that is also common in people with a certain type of prostate cancer.

“It’s still not clear if the virus, called XMRV, causes chronic fatigue syndrome (CFS), or is just more common in people with the disorder. But the discovery is sure to reignite the debate over whether CFS is fundamentally a psychological condition or a physiological one….”   Full article

 

A much briefer report appears in this week’s New Scientist print edition Magazine issue 2730

New Scientist

Upfront  New Scientist  | Page 6  |  17 October 2009

Virus in the frame  (headline used in print version)

“ALL in the mind, or all in a virus?

“Chronic fatigue syndrome, once dismissed as “yuppie flu”, has been linked to a virus that is also common in people with a certain type of prostate cancer.

“It’s still not clear if the virus, called XMRV, causes chronic fatigue syndrome (CFS), or is just more common in people with the disorder. But the discovery has reignited debate over whether CFS is psychological or physiological…”   Full article

Online copy of print version at:

14 October 2009

http://www.newscientist.com/article/mg20427302.900-chronic-fatigue-syndrome-linked-to-cancer-virus.html

NB: The online copy of the print edition report uses the same headline as the longer article published online on 8 October: Chronic fatigue syndrome linked to ‘cancer virus’

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Pro Health   15 October 2009

http://www.prohealth.com/library/showarticle.cfm?libid=14930

Don’t Miss the New York Times Q&A on XMRV by Dr. Klimas

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New York Times Consults Blog  15 October 2009

http://consults.blogs.nytimes.com/2009/10/15/readers-ask-a-virus-linked-to-chronic-fatigue-syndrome/

Readers Ask: A Virus Linked to Chronic Fatigue Syndrome
By The New York Times

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Update on Science Friday: Tom Kindlon reports via Co-Cure

The website http://www.sciencefriday.com/  lists it in the Hour One slot (i.e. 2-3pm EST).

It’s item 3 of 3 in that slot which may means its on between 2.30-3pm.

Don’t forget one can ring in to ask a question (and maybe make a point at the same time!?)

 

Science Friday    16 October 2009

http://www.sciencefriday.com/program/archives/200910163

A Virus and Chronic Fatigue? (broadcast Friday, October 16th, 2009)

Science Friday is a weekly science talk show, broadcast live over public radio stations nationwide from 2-4pm Eastern time as part of NPR’s ‘Talk of the Nation’ programming. Each week, we focus on science topics that are in the news and try to bring an educated, balanced discussion to bear on the scientific issues at hand.

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VIDEO Klimas on XMRV Added by Dan Moricoli    15 October 2009

http://cfsknowledgecenter.ning.com/video/klimas-on-xmrv

Taped Oct. 12th 2009 in her office. Dr Klimas talks about XMRV, what it means, what’s next and what you can do.

[Ed: You may need a membership of CFS Knowledge Centre network to access the video.]

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From Co-Cure mailing list    14 October 2009

DFW CFIDS reports:

Cheney, Peterson, Defreitas – history of the search for a retroviral link to CFS

(Dr. Paul Cheney asked me to post the following article written by him.)

A retrovirus XMRV is linked to Chronic Fatigue Syndrome
Paul R. Cheney MD, PhD
The Cheney Clinic, Asheville, NC
October 2009

www.cheneyresearch.com
www.cheneyclinic.com  

Recently published in Science (2009)[i] out of the Whittemore-Peterson Institute in Reno, NV along with The Cleveland Clinic and the National Cancer Institute (NIH) is the first convincing association of an isolated retrovirus with CFS. The gammaretrovirus XMRV was only recently discovered in 2007 at the Cleveland Clinic[ii] and cultured out of prostate cancer tissue from prostate cancer victims who had a rare mutation in the anti-viral RNase-L pathway. CFS patients also have unusual alterations in the same anti-viral pathway (1997)[iii] though different in its detail and far less rare.

Dan Peterson MD, a long time resident of Incline Village, NV (Lake Tahoe) and I worked for over eight years (1984 1992) to link CFS to a retrovirus. Dan first sent five CFS patient samples to Specialty Labs in 1985 to test for HTLV-1 and 4 of 5 were positive. We did this due to incredible disturbances on flow cytometry of peripheral mononuclear cells producing elevated CD4/CD8 ratios due to CD8 depletion as well as scatter patterns (debris patterns) that the laboratory flow cytometrist said she had only seen in HIV infections.

A radiologist at UC San Diego, on review, said our MRI brain scans done on CFS cases showing UBO’s (1988)[iv], looked exactly likes AIDS cases. Repeat testing was negative for HTLV-1 and Dr. James Peters of Specialty Labs suggested these CFS patients might have a cross reacting and novel retrovirus that looks like HTLV-1.

In 1986, I called the NCI and Robert Gallo MD, head of the foremost retrovirology laboratory in the world at the time, accepted Lake Tahoe samples for a year resulting in the association of an HHV-6A strain with Lake Tahoe CFS cases (1992)[v], only previously linked to HIV infection.

While practicing in Charlotte, NC and based on continued evidence of unusual immune disturbances by flow cytometry including CD4 depletion (ICL) in 15% of CFS patients which was investigated in my clinic and dismissed by the CDC in 1991 and continued high RNase-L activity (1994)[vi], I contacted Elaine DeFreitas PhD at the Wistar Institute in Philadelphia at the University of Pennsylvania who ultimately found HTLV-II-like genes associated with CFS (1991)[vii]. Her work was unfortunately assaulted by the CDC that claimed either an endogenous RV sequence that lighted up in cases and controls using her primers (per Dr. J.W. Gow) or null responses to cases and controls (per CDC scientist).

Elaine argued that these two scientists with diametrically opposing results manipulated the magnesium concentration which affects the primer stringency and got whatever result they wanted, to make their opposite claims. Her proposal to fly CDC scientists to Philadelphia to run the assays side by side with the her in her lab to see if these results could be replicated was dismissed by the CDC based on “lack of funds to buy plane tickets” from Atlanta to Philadelphia. Dr. Gow would later publish his opinion (1992)[viii]. Left unfunded by senior administrators at the NIH and the CDC, the search for a retroviral link in CFS dissipated and was lost until Judy Mikovits PhD, operating out of the independent Whittemore-Peterson Institute, revived the long search. I congratulate her and the Whittemore-Peterson Institute.

The finding of antibody or active virus in 95% of CFS and 4% of controls is a result that argues for causality, in my opinion, especially with the associated RNase-L[ix] corruption and NK functional impairment[x] that might predict such an infection. This novel retrovirus could easily shift the redox state just like HIV as has been published in (2001)[xi] and (1995)[xii] and induce all manner of associated pathogens as seen in CFS[xiii],[xiv],[xv],[xvi],[xvii]. A redox shift could ultimately corrupt the gut ecology and create P450 decoupling based on NADPH depletion observed in CFS and lead to environmental illness as well.

Time will tell but I think Dr. Mikovits is right to suspect causality. I also think this virus is infectious with at least ten million Americans infected who appear healthy and perhaps another 4 million Americans or more with CFS as recently estimated by the CDC (2007)[xviii]. However, disease expression may be more limited causing the illusion that it is not infectious. Furthermore, there may be other diseases that are similar and dissimilar to CFS that are associated with if not caused by XMRV.

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[i] Vincent C. Lombardi,1* Francis W. Ruscetti,2* Jaydip Das Gupta,3 Max A. Pfost,1 Kathryn S. Hagen,1 Daniel L. Peterson,1 Sandra K. Ruscetti,4 Rachel K. Bagni,5 Cari Petrow-Sadowski,6 Bert Gold,2 Michael Dean,2 Robert H. Silverman,3 Judy A. Mikovits1† “Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome” Science – epub ahead of publication – 8 October 2009, pp 4-10, science.1179052, www.sciencexpress.org

[ii] Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH “An infectious retrovirus susceptible to an IFN antiviral pathway from Human prostate tumors” (2007) Proc Natl Acad Sci USA 104:1655–1660.

[iii] Suhadolnick RJ, Peterson DL, O’Brien K, Cheney PR, Herst CVT, Reichenbach NL, Kon N, Horvath SE, Iacono KT, Adelson ME, De Meirleir K, De Becker P, Charubala R and Pfleiderer W “Biochemical Evidence for a Novel Low Molecular Weight 2-5A-Dependent RNase L in Chronic Fatigue Syndrome” Journal of Inteferon and Cytokine Research 17:377-385 (1997)

[iv] Buchwald D, Biddle R, Josesz FA, Kikinis R, Cheney PR, Peterson D, Komaroff AL, “Central Nervous System Abnormalities on Magnetic Resonance Imaging (MRI) in an Outbreak of Chronic Fatigue Syndrome (CFS)”, Presented at the American Federation for Clinical Research Annual Meeting, San Diego, CA 1988

[v] Buchwald,D., Cheney, PR., Peterson,DL., Henry,B., Wormsley,SB., Geiger,A., Ablashi,DV., Salahuddin,Z., Saxinger,C., Biddle,R., Kikinis,R., Jolesz,FA., Folks,T., Balachandran,N., Peter,JB., Gallo,RC.,and Komaroff,AL., “A Chronic Illness Characterized by Fatigue, Neurologic and Immunologic Disorders, and Active Human Herpesvirus-6 Infection”, Annals of Internal Medicine, Jan. 15, 1992:11 (2), pp.103-113.

[vi] Suhadolnik, RJ., Reichenbach,NL., Hitzges,P., Adelson,ME., Peterson,DL., Cheney, PR., Salvato,P.,  Thompson,C., Loveless,M., Muller,WG., Schroder,HC., Strayer,DR., and Carter,WA., “Changes in the 2-5A Synthetase/RNase L Antiviral Pathway in a Controlled Clinical Trial with Poly(1)-Poly(C12U) in Chronic Fatigue Syndrome”, In Vivo, 8:599-604, (1994).

[vii] Buchwald,D., Cheney, PR., Peterson,DL., Henry,B., Wormsley,SB., Geiger,A., Ablashi,DV., Salahuddin,Z., Saxinger,C., Biddle,R., Kikinis,R., Jolesz,FA., Folks,T., Balachandran,N., Peter,JB., Gallo,RC.,and Komaroff,AL., “A Chronic Illness Characterized by Fatigue, Neurologic and Immunologic Disorders, and Active Human Herpesvirus-6 Infection”, Annals of Internal Medicine, Jan. 15, 1992:11 (2), pp.103-113.

[viii] J W Gow, K Simpson, A Schliephake, W M Behan, L J Morrison, H Cavanagh, A Rethwilm, P O Behan “Search for retrovirus in the chronic fatigue syndrome” Journal of Clinical Pathology 1992;45:1058 1061

[ix] Suhadolnick RJ, Peterson DL, O’Brien K, Cheney PR, Herst CVT, Reichenbach NL, Kon N, Horvath SE, Iacono KT, Adelson ME, De Meirleir K, De Becker P, Charubala R and Pfleiderer W “Biochemical Evidence for a Novel Low Molecular Weight 2-5A-Dependent RNase L in Chronic Fatigue Syndrome” Journal of Inteferon and Cytokine Research 17:377-385 (1997)

[x] Caligiuri M, Murry C, Buchwald D, Levine H, Cheney PR, Peterson DL, Komaroff AL, and Ritz R, “Phenotypic and Functional Deficiency of Natural Killer Cells in Patients with Chronic Fatigue Syndrome”. J Immunology 1987; 139: 3306-

[xi] Ricard MJ, Favier A et al “HIV-1 Tat protein impairs selenoglutathione peroxidase expression by a mechanism independent of cellular selemium uptake: consequences on cellular resistance to UV radiation. Arch Biochem Biophys. 2001 Feb 15: 386(2):213-20

[xii] Westendorp MO, Lehmann V et al – German Cancer Research Center, Heidelberg) “HIV-1 Tat gene activates NF-kB via TNF-a and associated with reduced MnSOD and GSH/GSSG ratio” EMBO J. 1995 Feb 1: 14(3):546-54

[xiii] Buchwald,D., Cheney, PR., Peterson,DL., Henry,B., Wormsley,SB., Geiger,A., Ablashi,DV., Salahuddin,Z., Saxinger,C., Biddle,R., Kikinis,R., Jolesz,FA., Folks,T., Balachandran,N., Peter,JB., Gallo,RC.,and Komaroff,AL., “A Chronic Illness Characterized by Fatigue, Neurologic and Immunologic Disorders, and Active Human Herpesvirus-6 Infection”, Annals of Internal Medicine, Jan. 15, 1992:116 (2), pp.103-113.

[xiv] Straus,SE., Tosato,G., Armstrong,G., Lawley,T., Preble,OT., Henle,W., Davey,R., Pearson,G., Epstein,J., Brus,I. and Blaese,RM., “Persisting Illness and Fatigue in Adults with Evidence of Epstein Barr Virus Infection”, Ann. Intern. Med.,102:7-16,1985.

[xv] W. John Martin, Li Cheng Zeng, Khalid Ahmed, Maju Roy, “Cytomegalovirus – Related Sequence in a Atypical Cytopathic Virus Repeatedly Isolated From a Patient with Chronic Fatigue Syndrome”, American Journal of Pathology, pgs. 440-451, Volume 145:(2), August,1994.

[xvi] Gow,JW., Behan,WMH., Clements,GB., Woodall,C., Riding,M., Behan,PO., “Enteroviral RNA Sequences Detected by Polymerase Chain Reaction in Muscle of Patients with Postviral Fatigue Syndrome”,Br. Med. J.,302:692-96,1991.

[xvii] Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms. G. L. Nicolson et al., Acta Pathol. Microbiol. Immunol. Scand.(APMIS) 2003; 111: 557-566

[xviii] Reeves WC, Jones JJ, Maloney E, et al (CDC). New study on the prevalence of CFS in metro, urban and rural Georgia populations. Population Health Metrics. 2007; 5(5).

 

From Co-Cure mailing list    14 October 2009

Pat Sonnett reports:

In his current edition of the Lyndonville News, Dr. Bell discusses his views on XMRV. The print version can be found at: http://www.davidsbell.com/PrintLynNewsV6N2.htm

He includes the following section about research in evaluating his “original Lyndonville kids.”

Lyndonville Research Group:

Lets revive the Lyndonville research group again (gasp). I would like to test the original Lyndonville kids for XMRV, and if any of you reading this became ill in the Lyndonville area around 1985, were 18 or under at the time, and want to be evaluated, please write to me at lynnews@davidsbell.com  . Even if you are feeling great now.

If you know anyone that falls into this category, please send the information to them so they can get in touch with Dr. Bell directly.

Media Round ups

Round up 9: Notice from Dr David Bell, Lyndonville News; Article by Paul R. Cheney MD, PhD:
http://wp.me/p5foE-2aQ

Round up 8: XMRV retrovirus study: Position statement from ME Association 14.10.09: http://wp.me/p5foE-2at

Round up 7: XMRV Retrovirus: Whittemore Peterson Institute: CFS: Media Round up 7: http://wp.me/p5foE-2aa 

Round up 6: XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study: Videos and audios: http://wp.me/p5foE-29L 

Round up 5: Supporting Online Material for XMRV Chronic Fatigue Syndrome study: http://wp.me/p5foE-299

Round up 4: XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study:
http://wp.me/p5foE-28F

Round up 3: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome retrovirus XMRV in the media: http://wp.me/p5foE-280

Round up 2: Science 9 October 2009: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome link to retrovirus: 08.10.09: http://wp.me/p5foE-27v

Round up 1: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome link to retrovirus: 09.10.09: http://wp.me/p5foE-272

XMRV Retrovirus: Whittemore Peterson Institute: CFS: Media Round up 7

XMRV Retrovirus: Whittemore Peterson Institute: CFS: Media Round up 7

WordPress Shortlink for this posting: http://wp.me/p5foE-2aa 

Media

NHS Choices

http://www.nhs.uk/news/2009/10October/Pages/Does-a-virus-cause-ME.aspx

The “Behind the Headlines” item – “Does a virus cause ME?” has now been shifted from the Category “Mental Health” to the Category “Neurology”.

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PULSE

http://www.pulsetoday.co.uk/story.asp?sectioncode=23&storycode=4123887&c=1

Very brief report and comment section

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BMJ News

http://www.bmj.com/channels/news.dtl

No coverage whatsoever.

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Wikipedia

Wikipedia stub: Xmrv http://en.wikipedia.org/wiki/Xmrv

Wikipedia article: Retrovirus http://en.wikipedia.org/wiki/Retrovirus

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Whittemore Peterson Institute

Source: Lois Ventura www.name-us.org    13 October 2009

Lois writes, “Below is a response I received following a thank you note to WPI. Patients and others may find the info helpful. Angelina Gordon gave permission to repost unedited only.”

Thank you for your interest in the Whittemore Peterson Institute and our new research findings on XMRV. We have been overwhelmed with both your encouraging comments and the volume of email and traffic to our web site. We are working on answering many of the general questions posed in the last few days. Individual specific questions will be evaluated and responded to as appropriate.

– XMRV Testing: The number one request has been “how do I get tested for XMRV?” The WPI is negotiating an agreement with a clinical laboratory to allow for limited testing. These limited test services will be made available as soon as possible and we will provide information on this website as to how the test can be requested. We cannot offer individual testing and results from our research lab. Please check back to our website for updates.

– Research Studies: If you are interested in possibly being selected to participate in ongoing or future WPI research studies, we are working on an interactive form for our website. It should be available in the next few days, and we encourage you to complete the form at Whittemore Peterson Institute for Neuro-Immune Disease. While every study has specific requirements and not all who volunteer will be accepted, your willingness to participate is both crucial and deeply appreciated.

– Becoming a Patient: WPI is currently constructing our new home on the campus of the University of Nevada School of Medicine. It will open in the summer of 2010. At this time we are not able to accept patients, but would be happy to add your name to our interest list. With the rapid pace of research discoveries, we hope that there will be new treatment and diagnostic options available when we celebrate the opening of the new building.

The discovery of XMRV in ME/CFS patients opens an entire new avenue of neuro-immune disease research and our discovery has brought to this field world-renown immunologists and retrovirologists. Our team of collaborators is working daily to translate our discoveries into new treatments as soon as possible.

The discovery also raises many new questions about the role of XMRV in these diseases, how it is spread, what new or existing treatments may help combat the virus, and how treating the virus might improve the health of patients. For access to what we know to date, please see our XMRV Q&A. We will update it regularly and keep you informed.

Whittemore Peterson Institute – XMRV Q & A

We know many of you have been waiting years for answers, accurate diagnoses and some kind of effective treatments. All of us are dedicated to finding these, and we will continue to work as hard and as quickly as possible. Please remain hopeful, and keep in contact with us via the website or email. Making sure we have all of your contact information will ensure we are able to contact you with further information as it becomes available to us.

Angelina Gordon, Whittemore Peterson Institute

Cort Johnson’s site and Blog

XMRV/XAND Info Center Now Up on Phoenix Rising

The discovery of the XMRV retrovirus in most chronic fatigue syndrome (ME/CFS) patients appears to be a demarcating point in the history of this illness. The publication of the study in Science, the most prestigious scientific journal in the world, by a stellar cast of researchers from the National Cancer Institute, the Cleveland Clinic and the Whittemore Peterson Institute prompted a flood of stories across the major media outlets and scientific publications including Nature, Scientific American, the New York Times, (two articles), NPR, Fox News, LA Times, etc.

Amid concerns that the blood supply was contaminated the NIH officials announced they’d already held a conference on the issue. The Whittemore Peterson Institute rapidly conferred a new name for what it believes are a cadre of XMRV diseases – XAND (X Related Neuroimmune Disorder).

Questions were quickly raised concerning prevalence, transmission, testing, treatment, etc.

Check out the below sections for more information on this startling find. The first page – a very long – contains an overview of what I’ve learned thus far. Much of it, of course, is subject to change.

Immense congratulations and thanks, of course, go to the WPI.

Check out the below sections for more information on this startling find. The first page – a very long – contains an overview of what I’ve learned thus far. Much of it, of course, is subject to change.

Game Changer: the overview: what happened, prevalence, transmission, diagnosis, related research, etc. – http://aboutmecfs.org/Rsrch/XMRV.aspx

Treatment Options- potential treatment optionshttp://aboutmecfs.org/Rsrch/XMRVIntro.aspx

Resource Page- links to articles, blogs, websiteshttp://aboutmecfs.org/Rsrcs/XMRVResources.aspx

Discussion Center- Discuss XMRV/XAND herehttp://forums.aboutmecfs.org/forumdisplay.php?f=54

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Media Round ups for the XMRV story:

Round up 7: XMRV Retrovirus: Whittemore Peterson Institute: CFS: Media Round up 7: http://wp.me/p5foE-2aa  (you are here)

Round up 6: XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study: Videos and audios: http://wp.me/p5foE-29L 

Round up 5: Supporting Online Material for XMRV Chronic Fatigue Syndrome study: 
http://wp.me/p5foE-299

Round up 4: XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study:
http://wp.me/p5foE-28F

Round up 3: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome retrovirus XMRV in the media: http://wp.me/p5foE-280

Round up 2: Science 9 October 2009: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome link to retrovirus: 08.10.09: http://wp.me/p5foE-27v

Round up 1: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome link to retrovirus: 09.10.09: http://wp.me/p5foE-272

XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study: Videos

XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study: Videos

WordPress Shortlink for this posting: http://wp.me/p5foE-29L

 

Collated in reverse date order

Nevada Newsmakers    9 October 2009

http://nevadanewsmakers.com/video/default.asp?showID=938

28 mins news broadcast: Sam Shad interviews Drs Annette Whittemore and Judy Mikovits for 15 mins.
Interview starts 3.32 mins in and closes at 18.31.

 

KCRA News    9 October 2009

TV news station broadcasting on channel 3 in Sacramento, California

http://www.kcra.com/video/21256489/index.html

News report [2.33] preceded by short advert. 

 
NPR (National Public Radio)    9 October 2009

http://www.npr.org/templates/story/story.php?storyId=113650222

Interview with Dr Dan Peterson [4.33]

 

YouTube Channel 

Radio 5 Live    9 October 2009 [3.00 mins Audio: phone interview with Dr Judy Mikovits]

YouTube Channel

Nevanda Newsmakers    6 April 2009

Part One [5.26]

Part Two [6.12]

YouTube Channel 

ktvn.com report    12 November 2008  [2.32]

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Media Round ups for the XMRV story:

Round up 6: XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study: Videos and audios: http://wp.me/p5foE-29L  (you are here)

Round up 5: Supporting Online Material for XMRV Chronic Fatigue Syndrome study: 
http://wp.me/p5foE-299

Round up 4: XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study:
http://wp.me/p5foE-28F

Round up 3: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome retrovirus XMRV in the media: http://wp.me/p5foE-280

Round up 2: Science 9 October 2009: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome link to retrovirus: 08.10.09: http://wp.me/p5foE-27v

Round up 1: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome link to retrovirus: 09.10.09: http://wp.me/p5foE-272

XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study

Whittemore Peterson Institute (WPI)   Chronic Fatigue Syndrome   CFS   FM   GWS   Retrovirus XMRV   xenotropic murine leukaemia virus-related   Science Express

XMRV Retrovirus: Whittemore Peterson Institute Chronic Fatigue Syndrome study

Media Round up 4

For previous postings:

WordPress Shortlink for Round up 4: http://wp.me/p5foE-28F

Round up 3: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome retrovirus XMRV in the media: http://wp.me/p5foE-280

Round up 2: Science 9 October 2009: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome link to retrovirus: 08.10.09: http://wp.me/p5foE-272

Round up 1: Whittemore Peterson Institute (WPI) Chronic Fatigue Syndrome link to retrovirus: 09.10.09: http://wp.me/p5foE-27v

—————-

KCRA News

TV news station broadcasting on channel 3 in Sacramento, California

http://www.kcra.com/video/21256489/index.html

[2.33 mins] preceded by short advert

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Wall Street Journal Health Blog (there is a comment section)

http://blogs.wsj.com/health/2009/10/08/the-virus-that-links-prostate-cancer-chronic-fatigue-syndrome/

Health Blog
The Virus That Links Prostate Cancer & Chronic Fatigue Syndrome

By Jacob Goldstein

“For a few years now, researchers have been looking at what role a virus called XMRV plays in prostate cancer. A study published today in Science suggests the virus may also be linked to chronic fatigue syndrome. But the picture is still cloudy, and it’s not clear whether the virus actually causes prostate cancer or CFS.”

Medical/science bloggers

Not Rocket Science

http://tinyurl.com/yf9u4xl

Ed Yong is an award-winning science writer based in London.

Virus linked to both chronic fatigue syndrome and prostate cancer
Category: Cancer • Medicine & health • Viruses
Posted on: October 8, 2009 2:00 PM

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Corpus Callosum

http://scienceblogs.com/corpuscallosum/2009/10/general_fatigue_of_the_insane.php

Corpus Callosum is written by a psychiatrist at a small community hospital somewhere in the USA.

General Fatigue of the Insane?
Category: Medicine • Public Health • Science News • Social Commentary
Posted on: October 12, 2009 9:04 AM

Videocast: Chronic Fatigue Syndrome Advisory Committee Meeting (Day 1)

If you don’t support the Reeves/empirical definition/criteria for CFS sign the petition at: http://CFSdefinitionpetition.notlong.com

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Chronic Fatigue Syndrome Advisory Committee Meeting (Day 1)

The videocast of Day 1 of the CFSAC meeting which took place on 27 May, Washington DC, is now available.  You will need RealPlayer to view this videocast which is world accessible.

The broadcast covers the entire proceedings of Day 1 and is 06:57:55 long but you can dip in and out (Agenda below). Video and audio quality is generally good and there are simultaneous subtitles but no signing.

I will add the videocast for Day 2 of proceedings to this page when it becomes available.

Transcripts of testimonies from patients, carers and medical professionals will eventually be archived on a website and I will flag up the URL when this has been issued.

http://videocast.nih.gov/ 

http://videocast.nih.gov/PastEvents.asp

Chronic Fatigue Syndrome Advisory Committee Meeting (Day 1)

Wednesday, May 27, 2009

Wanda K. Jones, DrPH, Deputy Assistant Secretary for Health (Women’s Health), Office of Public Health and Science
Total Running Time: 06:57:55

Category: Advisory Boards

Agenda

http://www.hhs.gov/advcomcfs/meetings/agendas/cfsac090527_agenda.html

CFSAC Agenda – May 27-28, 2009
U.S. Department of Health and Human Services
CHRONIC FATIGUE SYNDROME ADVISORY COMMITTEE

Meeting
Wednesday, May 27, 2009
9:00 a.m. to 5:00 p.m.

Thursday, May 28, 2009
9:00 a.m. to 4:00 p.m.

Room 800, Hubert H. Humphrey Building
200 Independence Avenue, S.W.
Washington, D.C. 20201

Agenda

Wednesday, May 27, 2009

9:00 a.m.
Call to Order
Opening Remarks

Roll Call, Housekeeping
Dr. James Oleske
Chair, CFSAC

Dr. Wanda Jones
Designated Federal Official

9:15 a.m.
Agency Updates: HRSA, SSA, NIH, FDA
Ex Officio Representatives

10:00 a.m.
CDC Update
Research Program Strategic Plan
Public Meeting
Next Steps
Dr. Mike Miller
Ex-Officio

12:00 p.m.
Public Comment
Public

1:00 p.m.
Subcommittee Lunch
Subcommittee Members

2:30 p.m.
Subcommittee Reports

Quality of Life
Education
Research
Committee Discussion Committee Members

4:00 p.m.
Public Comment
Public

5:00 p.m.
Adjourn