XMRV Retrovirus Whittemore Peterson Institute Science Mikovits Chronic Fatigue Syndrome
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XMRV Retrovirus: CFSAC meeting Day Two
The Chronic Fatigue Syndrome Advisory Committee (CFSAC) provides advice and recommendations to the Secretary of Health and Human Services via the Assistant Secretary for Health of the U.S. Department of Health and Human Services on issues related to chronic fatigue syndrome (CFS).
Wanda K. Jones, DrPH is the CFSAC Designated Federal Official Deputy Assistant Secretary for Health – Women’s Health. For more information, visit http://www.hhs.gov/advcomcfs
For those who won’t be attending Day Two of the CFSAC meeting, today, Friday 30th October, the meeting is being videocast. Time displayed on the NIH site is Eastern Time, Washington DC Local. UK is currently 4 hours ahead of Washington DC – so 9:00 a.m. Washington DC is 13:00 hours UK time.
If you’re not able to catch all of today’s meeting or missed parts of yesterday’s, videocasts of the entire proceedings will be available shortly from the NIH wesbite ( http://videocast.nih.gov/PastEvents.asp ). I will post the links once these are online.
The CFCAS meeting will begin to stream live from the meeting room a few minutes before 1.00 p.m. UK time, with the audio off. Microphones are turned on just before the meeting is called to order – so don’t think you haven’t got sound. There are simultaneous subtitles. Today’s meeting is scheduled to adjourn at 4.00 p.m. Washington time (8.00 p.m. UK time). To watch the full day’s proceedings go to this link and scroll down to:
http://videocast.nih.gov/ RealPlayer required
Chronic Fatigue Syndrome Advisory Committee Meeting (CFSAC) – Day 2
Day 2 Friday 30th October 9:00 a.m. to 4:00 p.m.
Agendas for Day One and Day Two are here: AGENDA
Yesterday’s meeting included presentations by Dr Dan Peterson, Dr John Coffin (co-author of the Science “Perspective” article) and Dr David Bell, who spoke on MSpB (FII).
Dr Bell’s PowerPoint Slides can be viewed here:
Clips of Dr Dan Peterson and Annette Whittemore: http://www.youtube.com/user/Khalyal
7 uploads so far
Also here with some patient testimonies:
Whittemore Peterson Website Q & A
Kelly reports via Co-Cure 29 October 2009
“An investigative journalism site in Atlanta just posted the following article about the CDC and Reeves.”
Advocates: Where was CDC for milestone in chronic fatigue syndrome research?
October 28, 2009 –
Looks like the CDC’s chronic fatigue syndrome research group, led by Dr. William C. Reeves, may have some ‘splaining to do today in Washington. A possible research breakthrough — the discovery of a correlation between CFS and a retrovirus related to the AIDS virus — has fired up the medical community in recent weeks. “This is going to create an avalanche of subsequent studies,” Dr. William Schaffner, an infectious disease expert at Vanderbilt University, told the New York Times this month. But will the Centers for Disease Control and Prevention play a role in that research? It hasn’t so far.
Patient community websites, blogs, commentaries
Cort Johnson’s Phoenix Rising website
Resources, Blog and Forums
Hillary Johnson, author of Osler’s Web
Inside the Labyrinth
BILL REEVES: THE DECIDER
October 24, 2009
“First, Do No Pharma”
Saturday, October 17, 2009
CFS Patient Advocate
Dr Marc-Alexander reports via Co-Cure
Source: NCBI PubMed
Date: 27 oktober 2009
Ref: The list below illustrates that so far, just 16 papers have been published on the XMRV.
XMRV papers published up to october 27, 2009
Hohn O, Krause H, Barbarotto P, Niederstadt L, Beimforde N, Denner J, Miller K, Kurth R, Bannert N.
Lack of evidence for xenotropic murine leukemia virus-related virus (XMRV) in German prostate cancer patients.
Retrovirology. 2009 Oct 16;6(1):92.
Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Silverman RH, Mikovits JA.
Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome.
Science. 2009 Oct 8.
Yan Y, Liu Q, Kozak CA.
Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor.
Retrovirology. 2009 Oct 7;6(1):87.
Schlaberg R, Choe DJ, Brown KR, Thaker HM, Singh IR.
XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors.
Natl Acad Sci U S A. 2009 Sep 22;106(38):16351-6.
Stang A, Petrasch-Parwez E, Brandt S, Dermietzel R, Meyer HE, Stuhler K, Liffers ST, Uberla K, Grunwald T.
Unintended spread of a biosafety level 2 recombinant retrovirus.
Retrovirology. 2009 Sep 22;6:86.
Hong S, Klein EA, Das Gupta J, Hanke K, Weight CJ, Nguyen C, Gaughan C, Kim KA, Bannert N, Kirchhoff F, Munch J, Silverman RH.
Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus related virus), a human retrovirus associated with prostate cancer.
J Virol. 2009 Jul;83(14):6995-7003.
Knouf EC, Metzger MJ, Mitchell PS, Arroyo JD, Chevillet JR, Tewari M,
Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells.
J Virol. 2009 Jul;83(14):7353-6.
Bisbal C, Salehzada T.
RNase L, a crucial mediator of innate immunity and other cell functions [French].
Med Sci (Paris). 2008 Oct;24(10):859-64.
Fischer N, Hellwinkel O, Schulz C, Chun FK, Huland H, Aepfelbacher M, Schlomm T.
Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.
J Clin Virol. 2008 Nov;43(3):277-83.
Dong B, Silverman RH, Kandel ES.
A natural human retrovirus efficiently complements vectors based on murine leukemia virus.
PLoS One. 2008 Sep 4;3(9):e3144.
Kim S, Kim N, Dong B, Boren D, Lee SA, Das Gupta J, Gaughan C, Klein EA, Lee C, Silverman RH, Chow SA.
Integration site preference of xenotropic murine leukemia virus- related virus, a new human retrovirus associated with prostate cancer.
J Virol. 2008 Oct;82(20):9964-77.
Summers K, Crespi B.
Molecular evolution of the prostate cancer susceptibility locus RNASEL: evidence for positive selection.
Infect Genet Evol. 2008 May;8(3):297-301.
McCormick AL, Brown RH Jr, Cudkowicz ME, Al-Chalabi A, Garson JA.
Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate.
Neurology. 2008 Jan 22;70(4):278-83.
A scientific journey through the 2-5A/RNase L system.
Cytokine Growth Factor Rev. 2007 Oct-Dec;18(5-6):381-8.
Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH.
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.
Natl Acad Sci U S A. 2007 Jan 30;104(5):1655-60.
Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL.
Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
PLoS Pathog. 2006 Mar;2(3):e25. Epub 2006 Mar 31.
(c) 2009 NCBI PubMed
The Definition Petition
Petition webpage: http://CFSdefinitionpetition.notlong.com
If you haven’t already signed it – sign the CFS Definition Petition today at: http://CFSdefinitionpetition.notlong.com